Updated 2026-06-16 · Ranked by patient reviews
The best med spa in Hilton Head Island, SC is Main Street Medical, a 4.8★ medical spa with 2,432 verified patient reviews, known for medical clinic. For 2026 it ranks #1 in Hilton Head Island, SC, ahead of Tiffany Nails Spa and Nail Talk and Spa.
Hilton Head Island, SC has 5 top med spas ranked below for 2026, ordered by patient rating and review volume from our directory of 10 providers in Hilton Head Island, SC. Main Street Medical leads the list with 4.8★ across 2,432 reviews. Each entry links to a full profile with services, pricing, hours, and reviews.
4.8★ from 2,432 patient reviews — the top review profile in Hilton Head Island, SC.
Medical clinic
| # | Med spa | Rating | Reviews | Specialties |
|---|---|---|---|---|
| 1 | Main Street Medical | 4.8★ | 2,432 | Medical clinic |
| 2 | Tiffany Nails Spa | 4.7★ | 1,015 | Nail salon |
| 3 | Nail Talk and Spa | 4.7★ | 942 | Nail salon |
| 4 | Wherever Wellness | 4.9★ | 685 | Weight loss service |
| 5 | The Art of Massage and Yoga Wellness Spa | 4.9★ | 281 | Med spa services |
Main Street Medical ranks #1 in Hilton Head Island, SC by patient rating and review volume (4.8★, 2,432 reviews). See the full Top 5 above.
Botox in Hilton Head Island, SC typically runs $10–$25 per unit. Most of the med spas ranked here offer it alongside fillers, laser, and skin treatments.
By patient rating combined with review volume (rating × the log of review count), the same transparent formula used across No BS Med Spa Reviews. Owner-operated locations are labeled. See /how-we-rank for the full methodology.